The information presented is intended for use in both initial and ongoing discussions about the scope of services and collaborative practice responsibilities of clinical pharmacists, particularly when physicians or medical administrators are exploring or being encouraged to consider incorporating or expanding clinical pharmacists within practices. This issue brief is intended to support specific conversations with medical directors, practice managers, compliance officers, information technology staff, and others involved in the operations of practices once the decision to incorporate or increase the number of clinical pharmacists within the practice has been made (www.accp.com/paib2)